Abstracts

Click the category for abstract reference details:

Population

Calverley PM, Tal-Singer R, Edwards L, et al. Does measuring lung mechanics during tidal breathing provide additional information about COPD? Baseline data from the ECLIPSE study. Am J Respir Crit Care Med. 2008;177:A144.

Goldman M, Celli B, Crim C, et al. Comparison of forced oscillation and airflow perturbation lung mechanics in a cohort of ECLIPSE subjects. Eur Respir J. 2009;3262.

Agustí A, Calverley PMA, Celli B, et al. COPD heterogeneity in the ECLIPSE cohort. COPD7. 2010; Abstract 10.

Aarli BB, et al. Expiratory flow limitation (EFL) detected non-invasively as a phenotypic characteristic of COPD. Eur Respir J. 2011;38(Suppl. 55):160s (Abstr. P925).

Agustí A, Calverley PMA, Celli B, et al. COPD hetrogeneity in the ECLIPSE cohort. COPD. 2011;8(1):39-51.

MacNee W, Augustí A, Calverley PMA, et al. Comorbidities in COPD, clinical associations and relations to outcomes. Am J Respir Crit Care Med. 2011;183:A2993.

Rutten EPA, Casaburi R, Watkins ML, et al. Association of low body mass index and subsequent changes with COPD Outcomes. Eur Respir J. 2011;38(Suppl. 55):621s.

Spruit MA, Polkey MI, Celli B, et al. Reduced 6MWD is associated with increased mortality and exacerbation-related hospitalization in COPD: The ECLIPSE study. Am J Respir Crit Care Med. 2011;183:A2251.

Vestbo J, Scanlon P, Edwards L, et al. 3-year decline in forced expiratory volume in one second (FEV1) in the ECLIPSE study with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2011;183:A1437.

Lainscak M, Edwards L, Anker SD, et al. Clinical impact of anaemia in patients with chronic obstructive pulmonary disease: results from the ECLIPSE study. Eur Respir J. 2012;40(suppl 56):13s.

Mullerova H, Locantore N, Jones PW. GOLD assessment of COPD patients: impact of symptoms assessment choice. Eur Respir J. 2012;40(suppl 56):279s.

Hanson C, Sayles H, Rutten E, et al. Dietary intake is associated with lung function in the ECLIPSE cohort. Am J Respir Crit Care Med. 2014;189:A549.

Kolsum U, Brightling C, Agusti A, et al. The prevalence and clinical characteristics associated with eosinophillic inflammation in COPD Patients from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) cohort. Am J Respir Crit Care Med. 2014;189:A2745.

Martin M, Almeras N, Després JP, et al. Fat distribution, body composition and COPD in ECLIPSE. Am J Respir Crit Care Med. 2015;191:A3419.

Rheault T, Wurst KE, Edwards L, et al. Evaluation of asthma/COPD overlap within the ECLIPSE study. Eur Respir J. 2015;46(suppl 59):PA4066.

Health Status (SGRQ/FACIT/CES-D)

Hanania, NA, Sharafkhaneh, A, Muellerova, et al. Characteristics associated with depressive symptoms (DS) in patients with COPD. Am J Respir Crit Care Med. 2009;179: A4046.

Rennard S, Edwards LD, Yates JC, et al. Association of anti-depressive medications with clinical outcomes in ECLIPSE. Eur Respir J. 2009;34:A448.

Sumner H, Kelsall A, Lazaar AL, et al. On behalf of the ECLIPSE investigators. Influences of smoking and COPD on objective cough frequency. Thorax. 2009;64;A15(S23).

Hanania NA, Müllerova H, Locantore NW, et al. On behalf of the ECLIPSE investigators. Determinants of depression in the ECLIPSE COPD cohort. Am J Respir Crit Care Med. 2010;October.

Müllerova H, Locantore N, Sharafkhaneh A, et al. Assessment of fatigue in a large COPD cohort. Eur Respir J. 2010;36(Suppl 54):68S.

Müllerova H, Locantore N, Tal-Singer R, et al. SGRQ-C distribution in the evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE) cohort: characteristics of COPD subjects with extreme score quintiles. Eur Respir J. 2010;36(Suppl 54):1011s. (Oral presentation)

Al-Shair K, Mullerova H, Locantore NW, et al. Fatigue significantly associated with COPD exacerbations: data from the ECLIPSE study. Am J Respir Crit Care Med. 2011;183:A3974.

Janssen D, Agusti A, Mullerova H, et al. The relationship between persistent systemic inflammation and symptoms of depression among patients with COPD in the ECLIPSE cohort. Eur Respir J. 2013;42(Suppl. 57):1025s.

Wilke S, Jones P, Mullerova H, et al. One-year change in health status and outcomes in chronic obstructive pulmonary disease. Eur Respir J. 2014;44(Suppl. 58):P4826.

Yohannes AM, Müllerova H, Li H, et al. One-year change in health status and outcomes in chronic obstructive pulmonary disease. Chest. 2014;146(4_MeetingAbstracts):33A.

Exacerbations

Anzueto A., Hurst J, Müllerova H, et al. Prevalence and characteristics of nonexacerbators in COPD gold stage 4. Results from the ECLIPSE cohort study. Eur Respir J. 2009;34(Suppl 53):164s.

Anzueto A, Wedzicha JA, Hurst JR, et al. Diagnosis of COPD exacerbations and their distribution based on GOLD severity stages. Data from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study. Am J Respir Crit Care. 2009;179:A1527.

Hurst JR, Vestbo J, Muellerova H, et al. The GOLD stage II frequent exacerbator: characteristics and implications. Eur Respir J. 2009;34(Suppl 53):605s.

Vestbo J, Hurst J., Muellerova H, et al. One-year exacerbation frequency and treatment in the ECLIPSE study cohort. Eur Respir J. 2009;34(Suppl 53):604s.

Vestbo J, Wedzicha J, Wouters E, et al. On behalf of the ECLIPSE investigators. Exacerbations, health status and exercise capacity in moderate - very severe COPD. Am J Respir Crit Care Med. 2009;179;A1517.

Wedzicha JA, Hurst JR, Vestbo J, et al. On behalf of the ECLIPSE investigators. Comparison of perceived exacerbation frequency in COPD patients and actual number of exacerbations - data from the ECLIPSE study. Am J Respir Crit Care Med. 2009;179:A1528.

Anzueto A, Müllerova H, Locantore N, et al. Occurrence and descriptors of severe COPD exacerbations in the ECLIPSE cohort. Am J Respir Crit Care Med. 2010;181:A2388.

Donaldson G, Mullerova H, Locantore NW, et al. Factors associated with change in COPD exacerbation frequency phenotype. Am J Respir Crit Care Med. 2011;183:A5362.

Maselli Caceres D, Mullerova H, Locantore N, et al. Risk factors and mortality for severe COPD exacerbations during the 3-year follow-up in the ECLIPSE cohort. Am J Respir Crit Care Med. 2011;183:A5374.

Benson VS, Muellerova H, Vestbo J, et al. Gastro-oesophageal reflux disease and exacerbations of COPD in a cohort of 2,135 COPD patients. Eur Respir J. 2015;46(suppl 59):PA4080.

Exercise Tolerance and Activity

Calverley P, Tal-Singer R, Edwards L, et al. Self-reported cardiovascular disease and exercise performance in stable COPD. Eur Respir J. 2009;34;A195.

Rutten EPA, Watkins ML, Locantore NW, et al. Discriminating effects of muscle wasting with low and normal BMI in COPD. European Society for Clinical Nutrition and Metabolism 2009;31st Congress.

Rutten E, Watkins M, Locantore N, et al. Extent of emphysema and low fat free mass in COPD. Eur Respir J. 2009;34;A2902.

Shrikrishna D, Albert P, Calverley PM, et al. Quadriceps weakness in GOLD stage II COPD: data from the ECLIPSE study. Eur Respir J. 2009;34;A3811.

Spruit MA, Watkins ML, Edwards LD, et al. Characteristics of patients with COPD and exercise limitation. Am J Respir Crit Care Med. 2009;179;A1556.

Alshair K, Muellerova H, Locantore N, et al. Fatigue components in COPD patients and controls using the FACIT-F Scale: data from the ECLIPSE study. Eur Respir J. 2011;38(Suppl. 55):650s.

Spruit MA, Op het Veld L, Albert P, et al. One-year stability of quadriceps muscle strength in patients with COPD: an ECLIPSE sub-study. Am J Respir Crit Care Med. 2011;183:A2035.

Waschki B, Spruit MA, Watz H, et al. Measurement of physical activity in patients with COPD in a multicentre setting: compliance and associations with clinical characteristics of the disease. Am J Respir Crit Care Med. 2011;183:A1483.

Polkey MI, Spruit MA, Edwards LD, et al. The minimal clinically important difference (MCID) for the six minute walk (6MW) test in COPD in relation to death. Eur Respir J. 2012;40(suppl 56):92s.

Joppa P, Franssen F, Tkacova R, et al. The combination of low fat-free mass and high fat mass is related to functional outcome and systemic inflammation in patients with COPD. Eur Respir J. 2014;44(Suppl. 58):P3570.

Genomics

Pillai SG, Ge D, Zhu G, et al. α-nicotinic acetylcholine receptor (CHRNA3/5) polymorphisms influence risk of chronic obstructive pulmonary disease (COPD). American Society of Human Genetics. 2008; 58th Annual Meeting.

Kong X, Coxson HO, Lomas D, et al. Genome-wide association (GWA) study of high resolution CT defined emphysema phenotypes in two independent COPD populations. Am J Respir Crit Care Med. 2009;179;A2444.

Pillai S, Kong X, Coxson HO, et al. Association analysis of two novel, replicated COPD susceptibility genes in the ECLIPSE cohort. Am J Respir Crit Care Med. 2009;179;A2739.

Cho M, Boutaoui N, Klanderman B, et al. A genome-wide association study in COPD identifies FAM13A as a susceptibility locus. Am J Respir Crit Care Med. 2010:181;A3736.

Kong X, Cho M, Anderson W, Coxson H, et al. Genome-wide association study in two independent COPD populations identifies variants in the BICD1 gene associated with emphysema. Am J Respir Crit Care Med. 2010:181;A3740.

Sørheim IC, Cho MH, Johannessen A, et al. Genetic determinants of lung function in COPD: a genome-wide association study. Eur Respir J. 2010;36(Suppl 54);S252-3.

Sørheim I, Cho M, Johannessen A, et al. Genome-wide association study of lung function in COPD. Am J Respir Crit Care Med. 2010:181;A4009.

Wan E, Cho M, Boutaoui N, et al. Genome-wide association study of body mass index and fat free mass index in COPD. Am J Respir Crit Care Med. 2010:181;A1538.

Wan E, Cho M, Boutaoui N, et al. Mitochondrial DNA polymorphisms are associated with COPD. Am J Respir Crit Care Med. 2010:181;A2921.

Brehm JM, Hagiwara K, Mariani TJ, et al. Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183:A1751.

Castaldi PJ, Cho MH, Litonjua AA, et al. The association of genome-wide significant spirometric loci with COPD susceptibility. Am J Respir Cell Mol Biol. 2011;183l A5522.

Cho MH, Castaldi PJ, Hersh CP, et al. A genome-wide association study in COPD identifies a susceptibility locus on chromosome 19q13. Am J Respir Crit Care Med. 2011;183:A2272.

Hersh CP, Qiu W, Cho MH et al. Genetics of sputum gene expression supports two distinct COPD susceptibility genes on chromosome 15q25. Am J Respir Crit Care Med. 2011;183:A1754.

Qiu W, Cho MH, Riley JH, et al. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One. 2011;6(9 e24395): doi:10.1371/journal.pone.0024395.

Siedlinski M, Cho MH, Bakke P et al. Genome-wide association study of smoking behaviors in COPD patients 19q13. Am J Respir Crit Care Med. 2011;183:A5688.

Singh D, Fox S, Riley JH, et al. Prediction of an exacerbation phenotype using blood transcriptomic markers. Am J Respir Crit Care Med. 2011;183:A2254.

Wan ES, Cho MH, Kong X, et al. Genome wide association study of exacerbation phenotypes in COPD. Am J Respir Crit Care Med. 2011;183:A2273.

Castaldi P, Qiu W, Cho MH, et al. Testing reported genetic determinants of lung function from large population-based studies: association with COPD and EQTL analysis. Am J Respir Crit Care Med. 2012;185:A2663. 

Hardin M, Cho MH, Wan ES, et al. A genome-wide association study of bronchodilator responsiveness in four cohorts with COPD. Am J Respir Crit Care Med. 2012;185:A1938.

McDonald M-L, Cho MH, Sorheim I-C, et al. Common genetic risk variants correlate with hypoxemia within COPD cases in a genome-wide association study. Am J Respir Crit Care Med. 2012;185:A5868.

Wan ES, Coxson HO, Edwards LD, et al. Genome-wide association studies of longitudinal change in lung function and CT emphysema in the ECLIPSE study. Am J Respir Crit Care Med. 2012;185:A2662.

Castaldi PJ, Cho MH, Qiu W, et al. Integrated eQTL and genetic association analysis in smokers with COPD identifies disease-associated eQTL loci. American Society of Human Genetics (ASHG) Meeting. 2013:A988T.

Cho MH, McDonald ML, Castaldi P, et al. A genome-wide association study of COPD in four non-hispanic white cohorts. Am J Respir Crit Care Med. 2013;187:A5514.

Hackermuller J, Ahnert P, Christ S, et al. Assessment of long noncoding RNA expression using whole transcriptome sequencing of COPD blood samples from the ECLIPSE cohort. Am J Respir Crit Care Med. 2013;187:A5513.

Hardin M, Cho MH, McDonald M-L, et al. A genome-wide meta-analysis of the response to inhaled bronchodilators among subjects with chronic obstructive pulmonary disease. Presented at American Society of Human Genetics (ASHG) Meeting. 2013:A313. 

Lee JH, Hunninghake GM, McDonald MN, et al. Genetic variants associated with total lung capacity in chronic obstructive pulmonary disease. American Society of Human Genetics (ASHG) Meeting. 2013:A928T.

Rumsey W, Larminie C, Miller B, et al. Gene Expression of mitochondrial oxidative phosphorylation and oxidative stress pathways are negatively affected by disease progression in the ECLIPSE COPD cohort. Am J Respir Crit Care Med. 2013;187:A1510.

Castaldi PJ, Estepar RSJ, Cho MH, et al. Integration of GWAS, eQTL, and ENCODE Data Identify Regulatory Variants and Cell Types Contributing to Patterns of Radiographic Emphysema. Am J Respir Crit Care Med. 2014;189:A5271.

Choudhury G, Lakhdar R, Drost E, et al. Telomere attrition in circulating white blood cells in COPD. Am J Respir Crit Care Med. 2014;189:A3987.

McDonald M, Cho M, Wan E, et al. Genetic epidemiology of COPD cachexia: “It’s more than being skinny.” Am J Respir Crit Care Med. 2014;189:A5813.

McDonald ML-N, Mattheisen M, Cho MS, et al. Beyond GWAS: probing the landscape between pathway associations, genome-wide associations and protein-protein interaction networks in chronic obstructive pulmonary disease. 64th Annual Meeting of The American Society of Human Genetics. 2014;A1082M.

Rabinovich RA, Choudury G, Lakhdar R, et al. Telomere attrition in circulating white blood cells in COPD relates to lung function and outcomes. Thorax. 2014;69(Suppl 2):A28.

Chen V, Shannon C, Hollander Z, et al. The effect of statins on blood gene expression in COPD. Am J Respir Crit Care Med. 2015;191:A1255.

Cho MH, Castaldi PJ, Hersh CP, et al. A genome-wide association study of emphysema and airway quantitative imaging phenotypes. Am J Respir Crit Care Med. 2015;191:A2849.

Croteau-Chonka DC, van den Berge M, Castaldi PJ, et al. Identification of disease-specific eQTLs in asthma and COPD cases but not healthy controls. Am J Respir Crit Care Med. 2015;191:A1054.

Hardin M, Cho MH, McDonal M-L, et al. Sex-specific genome-wide analysis reveals novel genetic associations with COPD. Am J Respir Crit Care Med. 2015;191:A1053.

Mayer RJ, Rumsey WL, Derbeneva O, et al. Association studies between European mtDNA haplogroups and risk of smokers developing COPD: a study in the ECLIPSE cohort. Am J Respir Crit Care Med. 2015;191:A2903.

Imaging

Coxson HO, Sharma S, Edwards L. Computed tomographic measurements of lung structure in males and females. Baseline data from the ECLIPSE study. Am J Respir Crit Care Med. 2008;177;A662.

Connor SC, Ubhi B, Fox SM, Griffin J, et al. LCMS and NMR metabolic profiling of COPD patients in ECLIPSE. Am J Respir Crit Care Med. 2009;179;A3778.

Coxson HO, Gietema HA, Bakke PS, et al. Contributions of airway wall thickening and emphysema to airflow limitation: evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE) study. Am J Respir Crit Care Med. 2009;179;A6200.

Coxson H, Watkins, Locantore N, et al. Extent of emphysema by computed tomography and associations to lung mechanics the evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE) study. Am J Respir Crit Care Med. 2010:181;A5136.

Rutten EPA, Locantore N, Watkins M, et al. Determining factors for the altered adipokine metabolism in women with COPD. Eur Respir J. 2010;36(Suppl 54):S90.

Coxson HO, Sharma S, Edwards L, et al. Relationship between Lung Volumes and the Extent of Emphysema as Assessed bu Computerized Tomography in the the ECLISPE Study. Am J Respir Crit Care Med. 2011;183:A5781.

Rutten EPA, Watkins ML, Locantore NW, Wouters EFM. Health-related quality of life is related to BMI and weight changes 3 years in patients with COPD. Am J Respir Crit Care Med. 2011;183:A2659.

Romme EAPM, Edwards LD, Williams MC, et al. Low CT bone radio density is associated with adverse clinical features and increased coronary artery calcification in COPD. Eur Respir J. 2012;40(suppl 56):12-13s.

Williams MC, Edwards L, Murchison J, et al. Coronary artery calcification in COPD is associated with adverse functional assessments and mortality. Eur Respir J. 2012;40(suppl 56):13s.

Biomarkers

Lomas DA, Silverman EK, Edwards LD, et al. Serum surfactant protein D (SP-D) is a lung derived biomarker for COPD that is responsive to treatment with oral corticosteroids. Eur Respir J. 2008;32;E3108.

MacNee W, Rennard S, Edwards L, et al. Utility of exhaled breath condensate pH as a biomarker in COPD remains undefined. European Respiratory Society 18th Annual Congress. 2008;32;E3117.

Rennard S, Tal-Singer R, Edwards L. Baseline sputum analysis in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study. Am J Respir Crit Care Med. 2008;177;A877.

Lomas DA, Silverman EK, Edwards LD, et al. Serum surfactant protein D is associated with exacerbations of COPD. Am J Respir Crit Care Med. 2009;179:A5352.

Miller B, Edwards L, Locantore N, et al. Blood biomarkers in COPD: results from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) cohort. Eur Respir J. 2009;34;A4468.

Rutten EPA, Watkins ML, Locantore NW, et al. Relation between circulating adipokines and CRP in COPD. European Society for Clinical Nutrition and Metabolism 2009; 31st Congress.

Sin D, Man S, Xing L, et al. Pulmonary and activation-regulated chemokine (PARC): a new lung-specific blood biomarker for COPD? Am J Respir Crit Care Med. 2009;179;A3763.

Singh D, Fox S, Clayton C, et al. Transcript profiling of COPD patients in the ECLIPSE study. Am J Respir Crit Care Med. 2009;179;A3779.

Vestbo J, Wouters EFM, Rennard S, et al. TNFα as a biomarker of systemic disease in COPD. Am J Respir Crit Care Med. 2009;179;A3781.

Ibrahim B, Basanta M, Dockry R, et al. Exhaled volatile organic compounds as potential biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010:181;A1012.

Plumb J, Riley JH, Celli B, et al. Increased IL-18 receptor expression in COPD lung macrophages. Am J Respir Crit Care Med. 2010;181:A3789.

Casaburi R, Clark R, Miller B, et al. Association of testosterone level with phenotypic characteristics and long-term outcomes of men with COPD in the ECLIPSE cohort. Eur Respir J. 2011;38(Suppl. 55):530s.

Esther CR, Lazaar AL, Bordonali E, et al. Elevated airway purines in chronic obstructive pulmonary disease. Chest. 2011;10:2471.

Ubhi BK, Cheng KK, Dong J, et al. Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. Metabomeeting 2011.

Ubhi B, Riley J, Lomas D et al. Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify pateints with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2011;183:A5523.

Berg I, Hanson C, Sayles H, et al. Vitamin D, vitamin D binding protein, and airflow in COPD. Am J Respir Crit Care Med. 2012;185:A3749.

Duvoix A, Miller B, Edwards L, et al. Soluble receptor for advanced glycation endproducts (sRAGE) is a biomarker of emphysema in the ECLIPSE cohort. Am J Respir Crit Care Med. 2012;185:A4504.

Sherwood K, Chen V, Hollander Z, et al. Proteomic signature in plasma of chronic obstructive pulmonary disease subjects can differentiate frequent exacerbators from non-exacerbators. Can Respir J. 2012;19:e41.

Wang C, Clark RV, Miller BE, et al. Impact of testosterone level on long-term outcomes of men with COPD and association with phenotypic characteristics in a longitudinal study, ECLIPSE. Endocr Rev. 2012;33:OR28-5.

Hollander Z, Chen V, Wilson-McManus JE, et al. Biomarkers of imminent COPD exacerbation. Am J Respir Crit Care Med. 2014;189:A5895.

Rabinovich RA, Choudury G, Lakhdar R, et al. Telomere attrition in circulating white blood cells in COPD relates to lung function and outcomes. Eur Respir J. 2014;44(Suppl. 58):P2033.

Rabinovich RA, Miller BE, Wrobel K, et al. Circulating desmosine relates to cardiovascular comorbidity, coronary artery calcification score (CACS), systemic inflammation and mortality in patients with COPD. Thorax. 2014;69(Suppl 2):A28-9.

Rumsey W. Mitochondrial DNA damage in smoking related pulmonary disease. 43rd Annual Meeting of the European Environmental Mutagen Society. 2014.

Chen V, Shannon C, Hollander Z, et al. Targeted module-based discovery of blood biomarkers for prognosing imminent COPD exacerbations. Am J Respir Crit Care Med. 2015;191:A5116.

Leeming DJ, Byrjalsen I, Sand JMB, et al. Biomarkers of tissue turnover are related to a three year change in FEV1 in patients with COPD within the ECLIPSE cohort. Eur Respir J. 2015;46(suppl 59):PA3988.

Leung JM, Hollander Z, Chen V, et al. Discovery of novel plasma protein biomarkers to diagnose acute COPD exacerbations using multiple reaction monitoring mass spectrometry. Am J Respir Crit Care Med. 2015;191:A2528.

Morrow JD, Hersh CP, Houston I, et al. Recapitulation of COPD-related lung tissue methylation signatures in blood. Am J Respir Crit Care Med. 2015;191:A3655.

Sand JMB, Leeming DJ, Byrjalsen I, et al. Biomarkers of extracellular matrix turnover predict COPD mortality in the ECLIPSE COPD cohort. Eur Respir J. 2015;46(suppl 59):PA3989.

Protocol

Vestbo J, Coxson H, Dawber F, et al. Evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE); COPD5. 2006.

Systems biology

Rennard S, Vestbo J, Silverman E, et al. Determination of COPD characteristics via Unsupervised clustering of the ECLIPSE cohort. Eur Respir J. 2011;38(Suppl. 55):762s.